DELONG, MITCHELL A.,STURDIVANT, JILL MARIE,HEINTZELMAN, GEOFFREY RICHARD,ROYALTY, SUSAN M.
申请号：
ES12007093
公开号：
ES2535716T3
申请日:
2009.01.15
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Compound according to formula (I): ** Formula ** any optical isomer, diastereomer or enantiomer of formula I or a solvate or physiologically acceptable salt thereof, wherein R1 is a phenyl group, a tetrazoyl group, a triazolyl group, a thienyl group, a thiophenyl group, a thiazolyl group, a purinyl group, a pyrimidyl group, a pyridyl group, a furanyl group, a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group, a cyclohexenyl group, a group cycloheptyl, an epoxy group, a tetrahydrofuranyl group, an azacyclopentyl group, an azacyclohexyl group, a piperidyl group or a substituted or unsubstituted homopiperidyl group, R7 is hydrogen, C1-C4 or cyano alkyl, R2 and R3 are independently hydrogen, hydroxyl, halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, amino, nitro, cyano, C1-C4 carbonyl, C1-C4 carbonylamino, C1-C4 alkoxy, C1-C4 sulfonyl, C1-C4 sulfonylamino, C1-C4 thioalkyl, C1-C4 carboxyl, cycloalkyl, heterocycloalkyl, aryl, C1-C4 alkyl-aryl, heteroaryl or C1-C4 alkyl-heteroaryl； or R2 and R3 combine to form a ring of at least five and at most eight member atoms, X is a carbonyl group, a sulfone, thiocarbonyl or methylene group, and R4 and R5 are independently, halogen, hydrogen, hydroxyl, alkyl, alkoxy, amino, carbonyl, cycloalkyl, heterocycloalkyl, aryl, C1-C4 alkyl-aryl, heteroaryl, C1-C4 alkyl-heteroaryl, alkenyl, alkynyl, nitro, cyano, C1-C4 carbonylamino, C1-C4 sulfonyl, C1-C4 sulfonylamino , C1-C4 thioalkyl or C1-C4 carboxyl, in which aryl is an aromatic carbocyclic group that is not substituted or substituted with a group selected from alkyl, alkoxy, heteroaryl, acyl, carboxyl, carbonylamino, nitro, amino, cyano, halogen and hydroxyl； heteroaryl is a monocyclic or bicyclic aromatic carbocyclic radical having one or more heteroatoms in the carbocyclic ring that is unsubstituted or substituted with a group selected from aryl, C1-C4-alkyl-aryl, amino, halogen, hydroxyl, cyano, nitro, carboxyl, carbonylamino and C1-C4 alkyl； cycloalkyl
