ANTICORPS MONO ET BISPECIFIQUE SE LIANT A HERG1 ET HERG1/INTEGRINE BETA 1

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专利权人:

UNIVERSITA' DEGLI STUDI DI FIRENZE;DI.V.A.L. TOSCANA S.R.L.

发明人:

ARCANGELI, ANNAROSA,DURANTI, CLAUDIA,CARRARESI, LAURA,CRESCIOLI, SILVIA

申请号：

CA3070643

公开号：

CA3070643A1

申请日:

2018.06.29

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

The present invention describes a bispecfic antibody composed of the variabledomains (VH and VL) of two antibodies,hERG1 mAb (which binds the extracellular domain S5-P of hERG1) and of (.beta.1integrin mAb TS2/16 or BV7, which bind the extracellulardomain of (.beta.1 integrin. The present invention relates also to a novelanti-hERG1 molecule bearing a Cys in position 95 of the VH domain.The invention describes also their application for diagnostic and therapeuticpurposes in oncology and other fields of medical sciences.

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