Mono and bispecific antibody binding to hERG1 and hERG1/integrin beta 1

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专利权人:

Universita' Degli Studi di Firenze;DI.V.A.L. Toscana S.R.L.

发明人:

ARCANGELI, Annarosa,DURANTI, Claudia,CARRARESI, Laura,CRESCIOLI, Silvia

申请号：

AU2018302356

公开号：

AU2018302356A1

申请日:

2018.06.29

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

The present invention describes a bispecfic antibody composed of the variable domains (VH and VL) of two antibodies, hERG1 mAb (which binds the extracellular domain S5-P of hERG1) and of β1 integrin mAb TS2/16 or BV7, which bind the extracellular domain of β1 integrin. The present invention relates also to a novel anti-hERG1 molecule bearing a Cys in position 95 of the VH domain. The invention describes also their application for diagnostic and therapeutic purposes in oncology and other fields of medical sciences.

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