The present invention relates to antibodies against Colony Stimulating Factor-1 Receptor (CSF-1R)(anti-CSF-1R antibody), methods for their production, pharmaceuticalcompositions containing saidantibodies, and uses thereof. CSF-1R contains 5 extracellular domains (ECDs,designated D1-D5),wherein ECD4 mediates CSF-1R dimerization. Mice were immunized with theextracellular domain ofCSF-1R to generate monoclonal antibodies, and antibodies were screened forthose that bind only withinECD4. The described antibodies can be used to treat cancer, bone loss, orinflammatory diseases, or totreat or prevent metastasis.
