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PROCESS FOR THE PRODUCTION OF ESTETROL INTERMEDIATES
专利权人:
Estetra S.P.R.L.
发明人:
PASCAL Jean-Claude,PASCAL Jean-Claude
申请号:
SI201230598
公开号:
SI2714710T1
申请日:
2012.06.01
申请国别(地区):
SI
年份:
2016
代理人:
摘要:
The present invention relates to a process for the preparation of a compound of formula (I) said process comprising the steps of: a) reacting a compound of formula (II), with an acylating or a silylating agent to produce a compound of formula (III), wherein P1 and P2 are each independently a protecting group selected from R2&minusSi&mdashR3R4, or R1CO&mdash, wherein R1 is a group selected from C1-6alkyl or C3-6cycloalkyl, each group being optionally substituted by one or more substituents independently selected from fluoro or C1-4alkyl R2, R3 and R4 are each independently a group selected from C1-6alkyl or phenyl, each group being optionally substituted by one or more substituents independently selected from fluoro or C1-4alkyl b) reacting the compound of formula (III) in the presence of palladium acetate or a derivative thereof to produce compound of formula (IV) and c) reacting the compound of formula (IV) with a reducing agent to produce compound of formula (I).
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