A method to modulate the concentration of one or more Hormones in a subject comprising administering a composition comprising a chemosensory receptor ligand, where composition is adapted to provide a ligand to one or more regions of the intestine of such subject.
BARON ALAIN D,BROWN MARTIN R,JONES CHRISTOPHER R,G.,FINEMAN MARK S.
申请号：
CL2013001085
公开号：
CL2013001085A1
申请日:
2013.04.19
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
Provided herein are methods of modulating hormone concentrations in a subject comprising the administration of a composition comprising a chemosensory receptor ligand, wherein the composition is adapted to deliver the ligand to one or more regions of the intestine of said subject. Also provided are methods directed to the modulation of circulating concentrations of one or more of GLP-1 (total), GLP-1 (active), GLP-2, oxyntomodulin, PYY (total), PYY 3-36, CCK, GIP, insulin, C-peptide, glycentin, uroguanylin amylin, and ghrelin (total), ghrelin (active) and glucagon.UN METODO PARA MODULAR LA CONCENTRACION DE UNA O MAS HORMONAS EN UN SUJETO QUE COMPRENDE LA ADMINISTRACION DE UNA COMPOSICION QUE COMPRENDE UN LIGANDO DEL RECEPTOR QUIMIOSENSORIAL, DONDE LA COMPOSICION ESTA ADAPTADA PARA SUMINISTRAR EL LIGANDO A UNA O MAS REGIONES DEL INTESTINO DE TAL SUJETO.
