LOTZE, MICHAEL T.,洛兹 麦可,洛茲 麥可,RITTHIPICHAI, KRIT,理堤皮海 克里,洛兹 麦可,洛茲 麥可,理堤皮海 克里
申请号：
TW107100513
公开号：
TW201837168A
申请日:
2018.01.05
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
Methods of expanding tumor infiltrating lymphocytes (TILs) using a tumor necrosis factor receptor superfamily (TNFRSF) agonist, such as a 4-1BB agonist, a CD27 agonist, a glucocorticoid-induced TNF receptor-related agonist, an OX40 agonist, a HVEM agonist, or a CD95 agonist, and uses of such expanded TILs in the treatment of diseases such as cancer are disclosed herein. In addition, in some embodiments, therapeutic combinations of TILs and TNFRSF agonists useful in the treatment of diseases such as cancer, including compositions, uses, and dosing regimens thereof, are disclosed herein.本發明揭示使用腫瘤壞死因子受體超家族(TNFRSF)促效劑(諸如4-1BB促效劑、CD27促效劑、經糖皮質素誘發之TNF受體相關性促效劑、OX40促效劑、HVEM促效劑或CD95促效劑)擴增腫瘤浸潤淋巴球(TIL)之方法，及此等經擴增之TIL在治療疾病(諸如癌症)的用途。另外，在一些實施態樣中，本發明揭示有用於治療疾病(諸如癌症)之TIL與TNFRSF促效劑的治療組合，包括彼之組成物、用途及給藥方案。
