CHARLTON STEVEN JOHN,LEBLANC CATHERINE,MCKEOWN STEPHEN CARL
申请号：
NZ60552811
公开号：
NZ605528A
申请日:
2011.07.14
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed are (2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)alkane carboxylic acid derivatives as represented by the general formula (Ia), or a pharmaceutically acceptable salt thereof, wherein: A is N or CH； R1 is H or alkyl； or R1 is -X-Y； or R1 is -W-R7-X-Y； or R2 is H, alkyl； or R2 is -X-Y； or R2 is -W-R7-X-Y； wherein either R1 or R2 is -X-Y or -W-R7-X-Y； R2a is hydrogen； or R2 and R2a taken together are oxo； R3 is H, alkoxy, OH or alkyl optionally substituted by one to 17 halogen atoms； R4 is H, alkoxy, OH or alkyl； R5 is aryl； -(C0-C4 alkyl)-4 to 14 membered heteroaryl, wherein the heteroaryl contains at least one heteroatom selected from N, O and S, wherein the aryl and heteroaryl are each optionally substituted by one to five Z substituents； R6 is aryl； -(C0-C4 alkyl)-4 to 14 membered heteroaryl, wherein the heteroaryl contains at least one heteroatom selected from N, O and S, wherein the aryl and heteroaryl are each optionally substituted by one to five Z substituents； W is alkylene optionally substituted by hydroxy, halogens or alkyl； X is alkylene optionally substituted by hydroxy, halogens or alkyl； Y is carboxy and alkoxycarbonyl； R7 is a divalent moiety represented by -O-, -NHC(O)-, -CH2=CH2- , -aryl-D-； -3 to 14 membered heterocyclyl-D-, wherein the heterocyclyl contains at least one heteroatom selected from N, O and S, wherein D is 0, S, NH or not present； Z is independently alkyl optionally substituted by one to 13 halogen atoms, alkoxy or halogen； R19 and R21 are each independently H or alkyl. Representative compounds include 7-(2-phenyl-3-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid, 7-(8-hydroxy-2,3-di-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid； 7-(7-hydroxy-6-oxo-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid； 7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b ]pyrazin-5(6H)-yl)heptanoic acid, 2-(3-((2,3-diphenyl-7,8-dihydropyrido[3,2-b]pyrazin-5(6H)-yl)methyl)phenoxy)acetic acid or 7
