BAKER, Stephen,HERNANDEZ, Vincent,SHARMA, Rashmi,NIEMAN, James,AKAMA, Tsutomu,ZHANG, Yong-Kang,PLATTNER, Jacob,ALLEY, Michael,SINGH, Rajeshwar,PHILLIPS, James G.,XIA, Yi,ZHOU, Huchen,KERAMANE, El Mehd
申请号：
ES08825921
公开号：
ES2655299T3
申请日:
2008.06.19
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound that has a structure according to the formula: ** (See formula) ** in which R * is H or a negative charge； C * is a carbon atom； and it is a stereocenter that has a configuration that is selected from (R) and (S)； R3 is -CH2NH2； Ra is H or -YR5； in which Y is O or S； R5 is selected from substituted or unsubstituted alkyl, H and substituted or unsubstituted heteroalkyl； or R5 is: ** (See formula) ** in which a is an integer selected from 1 to 10 and optionally selected from 1 to 5； each R10 and each R11 is independently selected from H, substituted or unsubstituted alkyl, OH and NH2； R12 is selected from H, R7, halogen, cyano, amidino, OR7, NR7R8, SR7, -N (R7) S (O) 2R8, -C (O) R7, -C (O) OR7, -C (O) NR7R8 wherein each R7 and each R8 is independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl ； and provided that Ra and R *, together with the atoms to which they bind, are optionally combined to form a substituted or unsubstituted 6 to 10 membered heterocycloalkyl ring； or a salt, hydrate, solvate or anhydride thereof； wherein the term "alkyl" means C1-C10 alkyl； and wherein the substituents for alkyl radicals are each independently selected from the group consisting of -R ', -OR',>； = O,>； = NR ',>； = N-OR', -NR'R ", -SR ', -halogen, -SiR'R "R"', -OC (O) R ', -C (O) R', -CO2R ', -CONR'R ", -OC (O) NR'R ", -NR" C (O) R ', -NR'-C (O) NR "R"', -NR "C (O) 2R ', -NR" "' - C (NR'R" R " ')>； = NR ", -NR " - C (NR'R ")>； = NR"', -S (O) R ', -S (O) 2R', -S (O) 2NR'R ", -NR" SO2R ', -CN, -NO2, -N3, -CH (Ph) 2, fluoro (C1-C4) alkoxy and fluoro (C1-C4) alkyl, in a number ranging from zero to (2m '+1), where m' is the total number of carbon atoms in the "alkyl" group, and in which R ', R ", R"', R " and R '' '' 'refer to each one independently
