MELNYK, ROMAN,ZHANG, ZHIFEN,TAM, JOHN,LACY, DANA BORDEN,SEEBACK, STACEY A.,CHUMBLER, NICOLE M.
申请号：
CA2939969
公开号：
CA2939969A1
申请日:
2015.02.17
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Clostridium difficile is a leading cause of antibiotic-associated infection in hospitals worldwide. There is a need for a vaccine to Clostridium difficile that can target toxic proteins, or that can elicit adequate immunity to prevent infection or reduce the severity of infection. Modified Clostridium difficile toxin A and B (TcdA and TcdB) proteins are described herein, which comprise mutations that reduce toxin A and B toxicity compared to the native toxin. The proteins described are highly similar to the native toxin of Clostridium difficile, but toxicity is reduced.
