Roman MELNYK,Zhifen ZHANG,John TAM,Dana Borden LACY,Stacey A. SEEBACK,Nicole M. CHUMBLER
申请号：
US15119323
公开号：
US20170008937A1
申请日:
2015.02.17
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Clostridium difficile is a leading cause of antibiotic-associated infection in hospitals worldwide. There is a need for a vaccine to Clostridium difficile that can target toxic proteins, or that can elicit adequate immunity to prevent infection or reduce the severity of infection. Modified Clostridium difficile toxin A and B (TcdA and TcdB) proteins are described herein, which comprise mutations that reduce toxin A and B toxicity compared to the native toxin. The proteins described are highly similar to the native toxin of Clostridium difficile, but toxicity is reduced.
