BAESCHLIN, DANIEL KASPAR,MAIBAUM, JUERGEN KLAUS,SELLNER, HOLGER
申请号：
CA2600973
公开号：
CA2600973C
申请日:
2004.11.25
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Disclosed are .delta.-amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amidecompounds of formula (I) and the salts thereof, having renin-inhibitingproperties. Also disclosed are pharmaceutical compositions comprising thesecompounds and methods of administering them for the treatment of hypertension,atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiachypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstablecoronary syndrome, diastolic dysfunction, chronic kidney disease, hepaticfibrosis, complications resulting from diabetes, such as nephropathy,vasculopathy and neuropathy, diseases of the coronary vessels, restenosisfollowing angioplasty, raised intra-ocular pressure, glaucoma, abnormalvascular growth, hyperaldosteronism, cognitive impairment, alzheimers,dementia, anxiety states and cognitive disorders.
