compound for use in the manufacture of a medicament for reducing the symptoms of a disease selected from the group consisting of muscular dystrophy, arthritis, craniocerebral trauma, spinal cord injury, sepsis, rheumatic disease, cancer atherosclerosis, type 1 diabetes, type 2 diabetes, leptospirosis kidney disease, glaucoma, retinal disease, aging, headache, aches, complex regional pain syndrome, cardiac hypertrophy, muscle wasting, catabolic disorders, obesity, fetal growth retardation, hypercholesterolemia, heart disease, chronic heart failure, ischemia / reperfusion, stroke, cerebral aneur
The present invention relates to compounds and methods which may be useful as treatments of neuromuscular diseases such as muscular dystrophy, and as inhibitors of NF-ºB for the treatment or prevention of muscular wasting disease, including muscular dystrophy.