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MATRIX METALLOPROTEINASE INHIBITORS
专利权人:
发明人:
申请号:
HK11112516.7
公开号:
HK1158621A
申请日:
2011.11.18
申请国别(地区):
HK
年份:
2012
代理人:
摘要:
The present invention relates to beta-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure beta-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over- activation of a matrix metalloproteinase using the compounds.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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