Promedicament inhibiteur d'ECI

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专利权人:

VERTEX PHARMACEUTICALS INCORPORATED

发明人:

申请号：

EP03020900.1

公开号：

EP1396492B1

申请日:

2001.05.18

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

This invention described an ICE inhibitor prodrug (I) having good bioavailability. Compound of formula (I) is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, inflammatory peritonitis, septic shock, pancreatitis, traumatic brain injury, organ transplant rejection, osteoarthritis, asthma, psoriasis, Alzheimer's disease, myocardial infarction, congestive heart failure, Huntington's disease, atherosclerosis, atopic dermatitis, leukemias and related disorders, myelodysplastic syndrome, uveitis or multiple myeloma. <；CHEM>；

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