The invention relates to anti-VLA-4 antibodies and binding fragments thereof. The invention further includes polynucleotides encoding said antibodies and binding fragments thereof and methods of manufacturing said antibodies and binding fragments thereof. The invention further includes methods of treating patients suffering from multiple sclerosis and/or epilepsy by administration of said antibodies and binding fragments thereof. The invention further includes methods of reducing the susceptibility to scrambling of a recombinant anti-alpha 4 antibody or a binding fragment thereof.本發明係關於抗VLA-4抗體及其結合片段。本發明進一步包括編碼該等抗體及其結合片段之聚核苷酸以及製造該等抗體及其結合片段之方法。本發明進一步包括藉由投與該等抗體及其結合片段來治療罹患多發性硬化症及/或癲癇症之患者的方法。本發明進一步包括降低重組抗α4抗體或其結合片段對擾亂之易感性的方法。
