The present invention is directed to antibodies and fragments thereof having binding specificity for TNF-α. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-TNF-α antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-TNF- α antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-TNF-α antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with TNF-α.本發明係針對具有TNF-α之結合專一性的抗體與其等之片段。本發明的另一個實施例係有關本文中說明的抗體,與其等之結合片段,其等係包含本文中說明的VH、VL與CDR多肽之序列,以及編碼其等之多核苷酸。本發明亦預期結合至一或多個功能或可偵測的部分之抗TNF-α抗體與或其等之結合片段的結合物。本發明亦預期製造該等抗TNF-α抗體與其等之結合片段的方法。本發明的實施例亦有關抗TNF-α抗體,或其等之TNF-α結合片段用於與TNF-α有關的疾病或障礙之診斷、評估與治療之用途。
