DUTZAR, BENJAMIN H.,杜萨 班杰明Ｈ,杜薩 班傑明Ｈ,ANDERSON, KATIE,安德生 凯蒂,安德生 凱蒂,KOVACEVICH, BRIAN R.,柯法席维屈 布莱恩Ｒ,柯法席維屈 布萊恩Ｒ,FELDHAUS, ANDREW L.,费德哈斯 安德鲁Ｌ,費德哈斯 安德魯Ｌ,LATHAM, JOHN A.,雷特汉 约翰Ａ,雷特漢 約翰Ａ,GARCIA-MARTINEZ, LE,杜萨 班杰明H,杜薩 班傑明H,安德生 凯蒂,安德生 凱蒂,柯法席维屈 布莱恩R,柯法席維屈 布萊恩R,费德哈斯 安德鲁L,費德哈斯 安德魯L,雷特汉 约翰A,雷特漢 約翰A
申请号：
TW103109575
公开号：
TW201444868A
申请日:
2014.03.14
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention is directed to antibodies and fragments thereof having binding specificity for HGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-HGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-HGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-HGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with HGF.本發明係有關具有針對HGF之結合特異性之抗體及其片段。本發明之另一實施例係關於本文所述之抗體及其結合片段，包含本文所述之VH、VL及CDR多肽之序列，及編碼其之聚核苷酸。本發明亦涵蓋結合至一或多個功能性或可偵測部分之抗HGF抗體及其結合片段之結合物。本發明亦涵蓋製造該等抗HGF抗體及其結合片段之方法。本發明之實施例亦關於抗HGF抗體及其結合片段之用途，其用於診斷、評估及治療與HGF相關之疾病及病症。
