ALLEGRETTI, PAUL,保罗 埃拉葛提,保羅 埃拉葛提,CHOI, SEOK-KI,崔锡基,崔錫基,FATHEREE, PAUL R.,保罗R 费瑟里,保羅R 費瑟里,GENDRON, ROLAND,罗兰 金德朗,羅蘭 金德朗,HUDSON, RYAN,雷恩 修森,雷恩 修森,JENDZA, KEITH,凯斯 珍达,凱斯 珍達,MCKINNELL, ROBERT MURRAY,罗伯特M
申请号：
TW097120375
公开号：
TWI406850B
申请日:
2008.05.30
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The invention is directed to compounds having the formula:wherein: Ar, r, n, X, R2-3and R5-7are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds methods of using such compounds and process and intermediates for preparing such compounds.本發明係針對具有下式之化合物:其中:Ar、r、n、X、R2-3及R5-7係如本說明書所定義,及其醫藥學上可接受之鹽。此等化合物具有AT1受體拮抗劑活性及奈溶酶(neprilysin)抑制活性。本發明亦針對包含該等化合物之醫藥組合物;使用該等化合物之方法;及製備該等化合物之方法及中間物。
