雙效抗高血壓劑农业专利-农业专业知识服务系统

发明人:: CHOI, SEOK-KI,崔锡基,崔錫基,GENDRON, ROLAND,罗兰　金德朗,羅蘭　金德朗,FATHEREE, PAUL R.,保罗Ｒ　费瑟里,保羅Ｒ　費瑟里,JENDZA, KEITH,凯斯　珍达,凱斯　珍達,MCKINNELL, ROBERT MURRAY,罗伯特Ｍ　麦克基尼,羅伯特Ｍ　麥克基尼,ALLEGRETTI, PAUL,保罗　埃拉葛提,保羅　埃拉葛提,MCMURTRIE,,罗兰金德朗,羅蘭金德朗,保罗R 费瑟里,保羅R 費瑟里,凯斯珍达,凱斯珍達,罗伯特M 麦克基尼,羅伯特M 麥克基尼,保罗埃拉葛提,保羅埃拉葛提

摘要：: The invention is directed to compounds having the formula:wherein: Ar, r, Y, Z, Q, A, X, and R5-7are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds； methods of using such compounds； and process and intermediates for preparing such compounds.本發明係針對具有下式之化合物：其中：Ar,r,Y,Z,Q,A,X及R5－7均如本專利說明書中所定義，及其藥學上可接受之鹽。此等化合物具有AT1受體拮抗劑活性與臬普溶素(neprilysin)抑制活性。本發明亦針對包含此種化合物之醫藥組合物；使用此種化合物之方法；及製備此種化合物之方法與中間物。