Angelika FREITAG,Andrea HAWE,Gianluca RINALDI,Alessandra DEL RIO
申请号：
US15536941
公开号：
US20170348225A1
申请日:
2015.12.17
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to novel liquid protein formulations, particularly arginine-free liquid pharmaceutical compositions of etanercept. The invention employs particular combinations and classes of buffer systems, tonicifiers, and sugar stabilisers, optionally alongside polar ionisable amino acids (e.g. aspartic acid, glutamic acid, histidine, and lysine), to afford a viable and storable drug product.
