Swidorski, Jacob,Chen, Yan,Sit, Sing-Yuen,Meanwell, Nicholas A.,Regueiro-Ren, Alicia,Chen, Jie,Liu, Zheng,Hartz, Richard, A.,Xu, Li
申请号:
AU2014218754
公开号:
AU2014218754B2
申请日:
2014.02.21
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, alkyl and alkenyl C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV: a compound of Formula I; a compound of Formula II; a compound of Formula III: and a compound of Formula IV. These compounds are useful for the treatment of HIV and AIDS.