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4-Oxadiazolyl-piperidine compounds and use thereof
专利权人:
PURDUE PHARMA LP
发明人:
TAFESSE, LAYKEA
申请号:
ES06829087
公开号:
ES2382712T3
申请日:
2006.11.21
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
Compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: Ar1 is phenyl unsubstituted or substituted with one or more R2 groups; Ar2 is phenyl unsubstituted or substituted with one, two, or three R2 groups; Ar4 is phenyl unsubstituted or substituted with one, two, or three R2 groups; G is -H, -C (O) (CH2) nCO2R4, -C (O) (CH2) nR4, - (C1-C5 alkylene) C (O) OR4.3 or - (C1-C5 alkylene) R5; R1 = -H, -C (O) NH2, -C (O) NHOH, -CO2R4, -CHO, -CN, - (C1-C4 alkyl), -C (O) NH (C1-C4 alkyl), - C (O) N (C1-C4 alkyl) 2, -CF3, -CHF2, -CH2F, R2 and R3 are each independently -halogen, -C1-C3 alkyl, -O (C1-C3 alkyl), -NH ( C1-C3 alkyl), - N (C1-C3 alkyl) 2, -CF3, or -OCF3; R4 = -H, -C1-C10 alkyl, -CH2O (C1-C4 alkyl), -CH2N (C1-C4 alkyl) 2, or -CH2NH (C1-C4 alkyl); R5 = -NH2, -NHSO2R4, -C (O) NH2, -C (O) NHOH, -SO2NH2, -C (O) NH (C1-C4 alkyl), -C (O) N (C1-C4 alkyl) 2, - SO2NH (C1-C4 alkyl), -SO2N (C1-C4 alkyl) 2, -H, -OH, -CN, -C3-C8 cycloalkyl, phenyl, naphthyl, antryl, phenanthryl, or heteroaryl (5 to 7 members), not being substituted or being substituted with one or more R2 groups each C3-C8 cycloalkyl, phenyl, naphthyl, antryl, phenanthryl, or heteroaryl (5 to 7 members); m = an integer that goes from 0 to 4; n = an integer ranging from 1 to 4; p = 0 or 1; and q = an integer ranging from 1 to 6.Compuesto de fórmula (I): o una sal farmacéuticamente aceptable del mismo, en donde: Ar1 es fenilo no sustituido o sustituido con uno o más grupos R2; Ar2 es fenilo no sustituido o sustituido con uno, dos, o tres grupos R2; Ar4 es fenilo no sustituido o sustituido con uno, dos, o tres grupos R2; G es -H, -C(O)(CH2)nCO2R4, -C(O)(CH2)nR4, -(alquileno C1-C5)C(O)OR4,3 ó -(alquileno C1-C5)R5; R1 = -H, -C(O)NH2, -C(O)NHOH, -CO2R4, -CHO, -CN, -(alquilo C1-C4), -C(O)NH(alquilo C1-C4), -C(O)N(alquilo C1-C4)2, -CF3, -CHF2, -CH2F, R2 y R3 son cada uno independientemente -halógeno, alquilo -C1-C3, -O(alquilo C1-C3), -NH(alquilo C1-C3), - N(alquilo C1-C3)2, -CF3, u -OCF3; R4 = -H
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