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N-pyridinyl acetamide derivatives as inhibitors of the Wnt signaling pathway
专利权人:
Redx Pharma PLC
发明人:
BHAMRA, Inder,BINGHAM, Matilda,TESTAR, Richard,SARGENT, Louise,DONOGHUE, Craig
申请号:
ES15782041
公开号:
ES2754349T3
申请日:
2015.10.08
申请国别(地区):
ES
年份:
2020
代理人:
摘要:
A compound of formula (I): ** Formula ** wherein het1 represents a heterocyclic ring system of members selected from unsubstituted or substituted: pyrazole, imidazole, oxazole, isoxazole, isothiazole, thiophene, furan, triazole, oxadiazole and thiadiazole, and when substituted, the ring system is substituted with 1, 2 or 3 groups independently selected at each occurrence of: halo, C1-4alkyl, haloC1-4alkyl, -ORA2, -NRA2RB2, -CN, -SO2RA2 and C3-6 cycloalkyl; het1 is attached to het2 and to - (CR1R2) mC (O) NR3-, wherein het2 and - (CR1R2) mC (O) NR3- are attached to non-adjacent het1 atoms; het2 is a 5- or 6-membered heterocyclic ring that may be unsubstituted or substituted, and when substituted the ring is substituted with 1, 2 or 3 groups selected independently at each occurrence of: halo, C1-4alkyl, haloC1-alkyl 4, -ORA1, -NRA1RB1, -CN, -NO2, -NRA1C (O) RB1, -C (O) NRA1RB1, -NRA1SO2RB1, -SO2NRA1RB1, - SO2RA1, -C (O) RA1, -C (O) OA1 and C3-6 cycloalkyl; het3 is a 5- or 6-membered heterocyclic ring or a phenyl ring that may be unsubstituted or substituted, and when substituted the ring is substituted with 1, 2 or 3 groups selected independently at each occurrence of: halo, C1- alkyl 4, C1-4 haloalkyl, -ORA1, -NRA1RB1, -CN, -NO2, -NRA1C (O) RB1, -C (O) NRA1RB1, - NRA1SO2RB1, -SO2NRA1RB1, -SO2RA1, -C (O) RA1, - C (O) OA1 and C3-6 cycloalkyl; R1 and R2 are independently selected at each occurrence from: H, halo, C1-4 alkyl, C1-4 haloalkyl, -ORA3, - NRA3RB3 and C3-6 cycloalkyl; R3 is selected from: H, C1-4 alkyl, C1-4 haloalkyl and C3-6 cycloalkyl; R4 is independently selected at each occurrence from: halo, C1-4 alkyl, C1-4 haloalkyl, -CN, -ORA4, - NRA4RB4, -SO2RA4, C3-6 cycloalkyl and C3-6 halocycloalkyl; m is selected from, 1, 2 or 3; n is selected from 0, 1 or 2; and RA1, RB1, RA2, RB2, RA3, RB3, RA4 and RB4 are independently selected at each occurrence from: H, C1-4 alkyl, C1-4 haloalkyl.Un compuesto de la fórmula (I):**Fórmula** en donde het1 representa un sistema
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