Marianne Hopkins;Charles Dinarello;Bruce C. Galton;John E. Thompson;Catherine Taylor;Leonid Reznikov;Adrienne Boone
发明人:
John E. Thompson,Bruce C. Galton,Catherine Taylor,Charles Dinarello,Leonid Reznikov,Adrienne Boone,Marianne Hopkins
申请号：
US13099171
公开号：
US20120129910A1
申请日:
2011.05.02
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFkB by inhibiting expression of apoptosis-specific eIF-5A.
