ANTISENSE OLIGONUCLEOTIDE MODULATION OF STAT3 EXPRESSION

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专利权人:

Isis Pharmaceuticals; Inc.

发明人:

Karras, James G.

申请号：

AU2013204996

公开号：

AU2013204996A1

申请日:

2013.04.13

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

#$%^&*AU2013204996A120130516.pdf#####ABSTRACT Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression and for promotion of apoptosis are provided. Methods for treatment of diseases, particularly inflammatory diseases and cancers, associated with overexpression or constitutive activation of STAT3 or insufficient apoptosis are also provided.

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