GILBERT, JONATHAN B.,WANG, BU,LOUGHHEAD, SCOTT,BERNSTEIN, HOWARD,SHAREI, ARMON R.,MOORE, FINOLA
申请号：
CA3023092
公开号：
CA3023092A1
申请日:
2017.05.03
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention provides methods for inducing tolerance and/or suppressing an immune response to an antigen by passing a cell suspension containing an anucleate cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell. In some embodiments, the anucleate cell is delivered to an individual and the antigen is delivered to and processed in a tolerogenic environment to induce tolerance and/or suppress an immune response to the antigen.
