The present invention discloses a tumor radiation probe of iodine -123 marker thymidine (FLT) analogue [123I]-IaraU. Commercial available uridine is used as the raw material for the synthesis of the precursor. A radioactive iodine-123 is marked on an alkaline group of uridine to obtain [123I]-IaraU, which is distinguishable from [18F] -FLT marking18F on a glycosyl group. Thereby, a novel tumor radiation probe is obtained. The marking procedures include mixing the marker precursor with Na [123I] solution, acetic acid and hydrogen peroxide solution, and the solution of chloroform and sodium hydroxide. The sonication time increases from 1 minute to 10 minutes, so that [123I]-IaraU has radiologically chemical purity of higher than 98% and radiological specific activity of not less than 0.196 GBq/umole, and the yield can increase from 8% to 40%. Its radioactive specific activity, yield and purity reach to the degree for the use in biological experiments. By means of establishing the radioactive marker of uridine analogue, the production cost can be effectively reduced..一種碘-123標誌胸腺嘧啶(FLT)類似物[123I]-IaraU之探針,係由一般商業上可取得之尿苷(Uridine)為原料,透過合成新型探針之前驅物與放射標誌,於尿苷上之鹼基上標誌[123I]而得[123I]-IaraU,係有別於[18F]-FLT於醣基上標誌18F而獲得新穎之腫瘤放射探針,其標誌方式係將標誌前驅物、Na[123I]溶液、乙酸與過氧化氫溶液、以及三氯甲烷與氫氧化鈉溶液混合後,將超音波震盪時間由1分鐘提高至10分鐘,使其放射化學純度在98%以上,放射比活度不低於0.196 GBq/umole,且放射產率可由8%轉為40%,顯示均已達到使用於生物實驗之程度。藉此透過建立尿苷類似物之放射性標誌物,進而達到有效降低生產成本。1...尿苷2...產物3...產物4...產物5...產物6...產物7...放射標誌前驅物8...放射性產物
