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Pyridone-2-one derivatives as modulators of the stress-activated protein kinase system
专利权人:
INTERMUNE INC; Inc.;Intermune
发明人:
Blatt, Lawrence M,Seiwert, Scott D,Beigelman, Leonid,Radhakrishnan, Ramachandran,BLATT LAWRENCE M,BLATT, LAWRENCE M,SEIWERT SCOTT D,SEIWERT, SCOTT D,BEIGELMAN LEONID,BEIGELMAN, LEONID,RADHAKRISHNAN RAMACHANDRAN,RADHAKRISHNAN, RAMACHANDRAN
申请号:
ES13154719
公开号:
ES2600460T3
申请日:
2006.05.09
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound that has the structure of Genera Ia: ** Formula ** Genero Ia; wherein R2 is CO-glucorunide, R1, R3, and R4 are independently selected from the group consisting of H, C1-C10 alkyl, substituted C1-C10 alkyl, C1-C10 alkenyl, C1-C10 haloalkyl, C1-C10 nitroalkyl , C1-C10 thioalkyl, C1-C10 hydroxyalkyl, C3-C10 alkoxy, phenyl, substituted phenyl, halogen, hydroxy, C1-C10 alkoxyalkyl, C1-C10 carboxy, C1-C10 alkoxycarbonyl, CO-uronide, CO-monosaccharide, CO- oligosaccharide and CO-polysaccharide; and X1, X2, X3, X4 and X5 are independently selected from the group consisting of H, halogen, C1-C10 alkoxy and hydroxy.Un compuesto que tiene la estructura del Genero Ia:**Fórmula** Genero Ia; en la que R2 es CO-glucorunida, R1, R3, y R4 se seleccionan independientemente del grupo que consiste en H, alquilo C1-C10, alquilo C1-C10 sustituido, alquenilo C1-C10, haloalquilo C1-C10, nitroalquilo C1-C10, tioalquilo C1-C10, hidroxialquilo C1-C10, alcoxi C3-C10, fenilo, fenilo sustituido, halogeno, hidroxilo, alcoxialquilo C1-C10, carboxi C1-C10, alcoxicarbonilo C1-C10, CO-uronida, CO-monosacarido, CO-oligosacarido y CO-polisacarido; y X1, X2, X3, X4 y X5 se seleccionan independientemente del grupo que consiste en H, halogeno, alcoxi C1-C10 e hidroxi.
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