1,3-DIOXOINDENE DERIVATIVES, THEREOF PHARMACEUTICALLY ACCEPTABLE SALT, METHOD OF OBTAINING THEREOF AND PHARMACEUTICAL ANTIVIRAL COMPOSITION, CONTAINING IT AS ACTIVE INGREDIENT
KOREJA RISERCH INSTITJUT OF KEMIKAL TEKNOLODZHI;KATOLIKE UNIVERSITEJT LEVEN K.U. LEVEN R EHND D;KOREJA RISERCH INSTIT'JUT OF KEMIKAL TEKNOLODZHI
发明人:
DZUNG Jang Sik (KR),ДЗУНГ Янг Сик (KR),LI Chong Kgo (KR),ЛИ Чонг Кго (KR),ChOI Ikhl Jang (KR),ЧОИ Ихл Янг (KR),KIM Khae Soo (KR),КИМ Хае Соо (KR),KIM Pil Kho (KR),КИМ Пил Хо (KR),KhAN Soo Bong (KR),ХА,DZUNG JANG SIK,ДЗУНГ Янг Сик,LI CHONG KGO,ЛИ Чонг Кго,CHOI IKHL JANG,ЧОИ Ихл Янг,KIM KHAE SOO,КИМ Хае Соо,KIM PIL KHO,КИМ Пил Хо,KHAN SOO BONG,ХАН Соо Бонг,NEHJTS JOKHAN,НЭЙТС Йохан,TIBO KHENDRIK JAN
申请号：
RU2014101179/04
公开号：
RU0002566761C2
申请日:
2012.06.18
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to novel 1,3-dioxoindene derivatives of structural formula 1 which can be applied for prevention or treatment of viral disease, caused by picornavirus. In formula 1 A1, A2, A3 and A4 is independently selected from the group, consisting of -H, C1-C10alkoxy, -NO2, -NR1R2 and -NR1(C=O)R2, where A4 does not exist, when Z3 represents nitrogen, and at least one of A1-A4 is not hydrogen； G represents -OH, -N3, C1-C10alkoxy, -O(C=O)R1, -O(C=O)OR1, -O(C=O)NR1R2, -NR1R2, -NR1(C=O)R2, -NR1(C=O)OR2, -NR1(C=O)-NR2R3, or D1, D2, D3 and D4 is independently selected from the group, consisting of -H, halogen, -OH, C1-C10alkoxy, C1-C10 linear alkyl or alkyl with side chain, C6aryl, - (CH2)n-(C=O)OR1, -O(C=O)R1, -(C=O)R1, -NO2, -NR1(C=O)R2 and -SR1, or substituents D2 and D3 together can form six-membered ring, where ring, formed by substituents D2 and D3, can include one or several heteroatoms, and heteroatom represents N, and where D4 does not exist, when Z1 represents nitrogen, and D2 does not exist, when Z2 represents nitrogen； E represents -H, -OH, -OR1, -O(C=O)R1, -O(C=O)OR1, -O(C=O)NR1R2, -NR1(C=O)R2 or -SR1； each R1, R2 and R3 independently represents hydrogen, non-substituted or phenyl-substituted C1-C10 linear alkyl or alkyl with side chain, C1-C10alkoxy, non-substituted or phenyl-substituted C1-C10 linear alkenyl or alkenyl with side chain, C3cycoalkyl or non-substituted C6aryl； each X and Y independently represents hydrogen or oxygen； Z1, Z2 and Z3 represent carbon or nitrogen； n is equal to integer number from 1 to 10； and stands for single or double bond. Invention also relates to method of obtaining claimed compounds and to pharmaceutical composition, which contains claimed compound.EFFECT: obtaining compounds for prevention or treatment of viral disease.16 cl, 5 tbl, 108 exИзобретение относится к новым производным 1,3-диоксоиндена структурной формулы 1, которые могут быть использованы для профилактики или
