STILZ, HANS ULRICH,WEHNER, VOLKMAR,HULS, CHRISTOPH,SEIFFGE, DIRK
申请号：
CA2220777
公开号：
CA2220777C
申请日:
1997.11.12
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to compounds of the formula I(see formula I)which are inhibitors of the adhesion and migration of leucocytes and/orantagonistsof the adhesion receptor VLA-4 which belongs to the group of integrins. Theinvention also relates to processes for their preparation, to the use ofcompounds ofthe formula I for the treatment or prophylaxis of diseases which are caused byanundesired extent of leucocyte adhesion and/or leucocyte migration or which areassociated therewith or in which cell-cell or cell-matrix interactions whichare basedon interactions of VLA-4 receptors with their ligands play a part, for exampleofinflammatory processes, of rheumatoid arthritis or of allergic disorders, andalso tothe use of compounds of the formula I for the production of pharmaceuticalsfor usein such diseases, and to pharmaceutical preparations which contain thecompoundsof the formula I.
