Buechler, Ying,Chiang, Kyle,Do, Minh-Ha,Lee, Darin,Piehl, Kristi,Thomas, Marc,Watkins, Jeffry D.,Wu, Chi-Fang,Mendlein, John D.
申请号：
AU2014233436
公开号：
AU2014233436B2
申请日:
2014.03.14
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.
