Chi-Fang Wu,Darin Lee,Jeffry D. Watkins,Kristi Piehl,Kyle P. Chiang,Marc Thomas,Minh-Ha Do,Ying Buechler,John D. Mendlein
申请号：
US16122231
公开号：
US10472618B2
申请日:
2018.09.05
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.
