Xiang Gao,Xujia Zhang,Hongtao Guan,Henning Thoegersen,Kristian Sass-Oerum,Lars Fogh Iversen,Per Noergaard,Sebastian Beck Joergensen,Kristian Tage Hansen,Yi Wang,Kilian Waldemar Conde Frieboes,Birgit W
申请号：
US15986961
公开号：
US20180339057A1
申请日:
2018.05.23
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to MIC-1 compounds. More specifically it relates to compounds comprising a MIC-1 polypeptide with an N-terminal amino acid extension and a protractor wherein the amino acid extension comprises 3 to 36 amino acid residues and where the MIC-1 polypeptide and the N-terminal amino acid extension together have a calculated pI lower than 6.5. The compounds of the invention have MIC-1 activity. The invention also relates to pharmaceutical compositions comprising such compounds and pharmaceutically acceptable excipients, as well as the medical use of the compounds.
