Fazel Shabenpoor,Mohammed Akhter Hossain,Ross Alexander David Bathgate,John Desmond Wade,Andrew Lawrence Gundlach
申请号：
US13821747
公开号：
US20140024592A1
申请日:
2011.09.08
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to biologically active relaxin polypeptides comprising a relaxin A chain and a B chain derived from a relaxin superfamily member, wherein the A chain comprises no intra-chain disulphide bonds. In particular embodiments the modified polypeptides comprise relaxin-3 derived A and B chains, and truncations of the A and/or B chains from the N-termini and/or C-termini. In particular embodiments the polypeptides of the invention are selective agonists or antagonists of the RXFP3 receptor.
