Howard Florey Institute of Experimental Physiology and Medicine
发明人:
Shabanpoor, Fazel,Hossain, Mohammed Akhter,Bathgate, Ross Alexander David,Wade, John Desmond,Gundlach, Andrew Lawrence
申请号：
AU2011301147
公开号：
AU2011301147A1
申请日:
2011.09.08
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The present invention relates to biologically active relaxin polypeptides comprising a relaxin A chain and a B chain derived from a relaxin superfamily member, wherein the A chain comprises no intra-chain disulphide bonds. In particular embodiments the modified polypeptides comprise relaxin-3 derived A and B chains, and truncations of the A and/or B chains from the N-termini and/or C-termini. In particular embodiments the polypeptides of the invention are selective agonists or antagonists of the RXFP3 receptor.
