Described herein are methods of treating a metabolic disorder in an individual in need thereof, comprising co-administering to the individual a therapeutically effective amount of an FXR modulator, and at least one second agent that is an CCR2/CCR5 antagonist, ASKl inhibitor, DPP-IV inhibitor, caspase protease inhibitor, SGLT2 inhibitor, acetyl-CoA carboxylase (ACC) inhibitor, diacyl glycerol acyltransferase-1 inhibitor, sodium -bile acid cotransporter-inhibitor, TLR-4 antagonist, PPAR alpha/delta agonist, or GLP-1 agonist, or a combination thereof.En la presente se describen métodos para tratar un trastorno metabólico en un individuo que lo necesita, que comprenden administrar de forma conjunta al individuo una cantidad terapéuticamente eficaz de un modular del FXR y al menos un segundo agente que es un antagonista de CCR2/CCR5, inhibidor de ASK1, inhibidor de DPP-IV, inhibidor de la proteasa de caspasa, inhibidor de SGLT2, inhibidor de acetil-CoA carboxilasa 8ACC), inhibidor de diacilgricerol aciltransferasa-1 inhibidor de cotrnsportadores de ácidos biliares sódicos, antagonista de TLR-4, agonista de PPAR alfa/delta, o agonista de GLP-1, o una combinación de estos.
