LI, YUN-LONG,BURNS, DAVID M.,FENG, HAO,HUANG, TAISHENG,MEI, SONG,PAN, JUN,VECHORKIN, OLEG,YE, HAI FEN,ZHU, WENYU,RAFALSKI, MARIA,WANG, ANLAI,XUE, CHU-BIAO
申请号：
CA2921959
公开号：
CA2921959A1
申请日:
2014.08.22
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present disclosure describes furo-and thieno-pyridine carboxamide compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: X is S or 0； A5 is N or C-R5. CyA is a 5 to 6 membered monocyclic heteroaryl group, wherein the ring atoms of the heteroaryl group forming CyA consist of carbon atoms and 1, 2, or 3 heteroatoms selected from N, 0 and S, and wherein the 5 to 6 membered monocyclic heteroaryl group forming CyA is unsubstituted or substituted with 1, 2, or 3 RA； CyB is C6-10aryl, C3-7cycloalkyl, 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl wherein the ring atoms of the ring atoms of the heteroaryl or heterocycloalkyl forming CyB consist of carbon atoms and 1, 2 or 3 heteroatoms selected from 0, N and S, and wherein each of said C6-10aryl, C3-7cycloalkyl, 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl forming CyB is unsubstituted or substituted with 1, 2, 3, 4 or 5 RB； R2 is H, halogen or NH2； and R5, R6 and R7 are as defined in claim 1； The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
