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Oligonucleotides for modulating target RNA activity
专利权人:
Mirx Therapeutics ApS
发明人:
MØLLER, Thorleif
申请号:
AU2014250708
公开号:
AU2014250708B2
申请日:
2014.10.17
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
#$%^&*AU2014250708B220161110.pdf#####85 Abstract The present invention describes oligonucleotides that bind to microRNA target 5 sites in target RNAs, such as mRNAs. The oligonucleotides of the invention may mediate RNase H degradation of the target RNA, mediate RNAi of the target RNA or prevent microRNA regulation of the target RNA. The oligonucleotides of the invention are useful e.g. as research tools for studying microRNA:mRNA interactions and for therapeutic development. The present invention also 10 describes methods of identifying microRNA target sites, methods of validating microRNA target sites, methods of identifying oligonucleotides of the invention and methods of modulating the activity of a target RNA using the oligonucleotides of the invention.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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