Chajut, Ayelet,Bennett, C. Frank,Yerushalmi, Noga,Marcusson, Eric G.,Esau, Christine
申请号：
AU2014271307
公开号：
AU2014271307A1
申请日:
2014.12.04
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
#$%^&*AU2014271307A120150115.pdf#####TARGETING MICRORNAS FOR THE TREATMENT OF LIVER CANCER Abstract: Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis. (4Oi%1R2 1il-G
