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Novel FXR (NR1H4) binding and activity modulating compounds
专利权人:
Inc.;Gilead Sciences
发明人:
KINZEL, Olaf,STEENECK, Christoph,KREMOSER, Claus
申请号:
AU2018203613
公开号:
AU2018203613A1
申请日:
2018.05.22
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
#$%^&*AU2018203613A120180614.pdf#####NOVEL FXR (NR1H4) BINDING AND ACTIVITY MODULATING COMPOUNDS ABSTRACT The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of disease and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds (1). Z is selected from (a), (b), (c) or (d). R A H Z Q R1 N N R1 O R1 N / N N R3 R3 R3 N R3 R2 R2 R2 R2 -- X (a), -X (b), 'X (c), -X (d).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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