An anti-protein adhesion inhibitor, a coating solution, a coating using the protein adhesion prevention agent, which is excellent in water resistance, a coating component is hardly eluted, a coating layer excellent in biocompatibility, which is difficult to adsorb proteins, can be easily formed, a coating solution A medical device having a layer, a manufacturing method thereof, and a fluorine-containing polymer used for the protein adhesion preventing agent. A fluoropolymer having a unit having a biocompatible group, a fluorine atom content of 5 to 60% by mass, and a proportion P represented by the following formula of 0.1 to 4.5% , Compounds for preventing protein adhesion. (Percentage P) = [(Proportion (mass%) of unit having biocompatible group to all units of fluoropolymer] / (Fluorine atom content (mass%) of fluorine-containing polymer)] 100.耐水性に優れ被覆成分が溶出しにくく、タンパク質が吸着しにくい生体適合性に優れた被覆層を簡便に形成できるタンパク質付着防止用防止剤、塗布液、該タンパク質付着防止用防止剤を用いた被覆層を有する医療用デバイス、その製造方法、および該タンパク質付着防止剤に用いる含フッ素重合体の提供。 生体親和性基を有する単位を有し、フッ素原子含有率が5~60質量%であり、かつ下式で表される割合Pが0.1~4.5%である含フッ素重合体を含む、タンパク質付着防止用化合物。 (割合P)=[(含フッ素重合体の全単位に対する生体親和性基を有する単位の割合(質量%))/(含フッ素重合体のフッ素原子含有率(質量%))]×100。
