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DI-aromatic substituted amides as inhibitors for GlyT1
专利权人:
F. Hoffmann-La Roche AG
发明人:
Narquizian, Robert,Pinard, Emmanuel,Jolidon, Synese
申请号:
AU2007287645
公开号:
AU2007287645B2
申请日:
2007.08.13
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The present invention relates to compounds of the general Formula (I) wherein(A) is a 5 or 6-membered aromatic or heteroaromatic ring; Ris cycloalkylor is aryl or heteroaryl, wherein at least one ring is aromatic in nature, unsubstitutedor substituted by 1 to 3 substituents selected from the group consisting of halogen,lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkoxysubstituted by halogen, -C(O) -lower alkyl, -S(O)-lower alkyl,nitro or cyano; R is hydrogen or lower alkyl; R is hydrogenor lower alkyl; R is halogen, lower alkyl, lower alkyl substitutedby halogen, lower alkoxy, lower alkoxy substituted by halogen or nitro; Ris hydrogen, halogen, lower alkyl or lower alkyl substituted by halogen; X isa bond, -(CH)-, -CHO- or -CHNH-;The dotted line denotes a bond or not; n is 1 or 2; m is 1, 2 or 3; and pharmaceuticallyacceptable acid addition salts thereof and their use in the treatment of neurologicaland neuropsychiatric disorders.
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