1. The compound represented by the following structural formula, or a pharmaceutically acceptable salt or prodrug thereof, wherein: n is 1, 2 or 3； m is 0 or 1； p is 0 or 1； t is 0, 1 or 2； y is 1 or 2； z is 0, 1 or 2； E is S, O, NH, NOH, NNO, NCN, NR, NOR or NSOR； X is CR when m is 1, or N when m is 0； X is O, —NH, —CH—, SO, NH — SO； CH (CC) -alkyl or -NR； X is O, -NH, -CH-, CO, -CH (CC) -alkyl, SONH, -CO-NH- or -NR； X is CRR, CHCRR or CH- ( CC) -alkyl-CRR； X is a direct bond, O, S, SO, CRR； (CC) -alkyl, (CC) -alkyloxy, (CC) -alkenyl, (CC) -alkenyloxy； R is (CC) -aryl, (CC) -heteroaryl, (CC) -alkyl, (CC) -heteroaryl - (CC) -alkyl； R is H, CN, (CC) -alkylcarbonyl or (CC) -alkyl； each of R and R is independently —H, (CC) -alkyl optionally substituted with one or more substituents selected from the group consisting of halogen (CC) -alkyl, (CC) -aryl, (CC) -heteroaryl, (CC) -alkyl- (CC) -aryl, halogen- (CC) -aryl and halogen- (CC) -heteroaryl or, optionally, when X is —NR and X is —NR, R and R together with atom the nitrogen to which they are attached form a non-aromatic heterocyclic ring optionally substituted with one or more substituents selected from the group consisting of halogen, (CC) -alkyl, (CC) -aryl, (CC) -heteroaryl, (CC) -alkyl - (CC) -aryl, halogen- (CC) -aryl and halogen- (CC) -heteroaryl； R and R are independently selected from H, (CC) -alkyl, or together with the carbon to which they are attached, they form a spiro A (CC) cycloalkyl ring or a spiro (CC) cycloalkoxyl ring； R is —H, halogen, —CN, (CC) aryl, (CC) aryloxy group (CC) alkyl igruppu； (C-C) -alkyl optionally substituted1. Соединение, представленное следующей структурной формулой,или его фармацевтически приемлемая соль или пролекарство, где:n равно 1, 2 или 3；m равно 0 или 1；p равно 0 или 1；t равно 0, 1 или 2；y равно 1 или 2；z равно 0, 1 или 2；E представляет собой S, O, NH, NOH, NNO, NCN, NR, NOR или NSOR；Xпредставляет собой CR, когда m равно 1, или N, когда m равно 0；Xпредставляет собой O, -NH
