INSULIN ANALOGUES OR DERIVATIVES HAVING AN EXTREMELY DELAYED TIME-ACTION PROFILE

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专利权人:

SANOFI-AVENTIS DEUTSCHLAND GMBH

发明人:

HABERMANN, PAUL,SEIPKE, GERHARD,KURRLE, ROLAND,MULLER, GUNTER,SOMMERFELD, MARK,TENNAGELS, NORBERT,TSCHANK, GEORG,WERNER, ULRICH

申请号：

NZ58659009

公开号：

NZ586590A

申请日:

2009.01.06

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Discloses insulin analogues with the general structure as shown in Formula 1 with amino acid substitutions in the A-chain and B-chain as disclosed. Further discloses a method for preparing the insulin analogues. Also discloses insulin analogues which further comprise an addition of a glucagon-like peptide-1 or extendin-3 or -4 molecule. The therapeutic application is in the treatment of diabetes by providing insulin analogues with long-lasting activity in vivo.

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