siRNA structures for high activity and reduced off target

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专利权人:

Nitto Denko Corporation

发明人:

Kenjirou Minomi,Jens Harborth,Cima Cina,Wenbin Ying,Jane Zheng,Narendra Vaish

申请号：

US15376633

公开号：

US10358647B2

申请日:

2016.12.12

申请国别(地区):

US

年份:

2019

代理人:

摘要：

This invention provides compounds, compositions and methods for modulating the expression of target genes using RNA interference. RNAi structures and molecules of this invention can be used for modulating or silencing the expression of genes, with high levels of RNAi activity and reduced off target actions. Advantageous structures include siRNAs targeted to any gene having one or more 2′；-deoxy nucleotides located in the seed region. The RNA interference molecules can be used in methods for preventing or treating diseases.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/