PROBLEM TO BE SOLVED: To provide a biopsy device that is fully disposable and configured to allow easy use while having efficient vacuum application to aid in sample acquisition.SOLUTION: A biopsy device includes a housing body and a cannula assembly. The cannula assembly has a first elongate cannula and a coaxial second elongate cannula. The second elongate cannula has a side wall and a lumen. The side wall has a vacuum side port in fluid communication with the lumen. A vacuum source positioned in the housing body has a chamber side wall and a chamber vacuum port. A seal is interposed in sealing engagement between the chamber vacuum port and the second elongate cannula. A trigger slide assembly is configured to move the second elongate cannula to align the vacuum side port of the second elongate cannula with the chamber vacuum port of the vacuum source to supply vacuum from the vacuum source to the lumen of the second elongate cannula.SELECTED DRAWING: Figure 1