Provided herein is a biopsy device, comprising a housing body defining a longitudinal axis. The device has a cannula assembly having a first elongate cannula having a first side wall configured to define a first lumen and an elongate side opening that extends through the first side wall. The cannula assembly has a second elongate cannula coaxial with the first elongate cannula. The second elongate cannula has a second side wall configured to define a second lumen and a cutting edge. The second side wall has a vacuum side port in fluid communication with the second lumen. The device further comprises a vacuum source positioned in the housing body, and having a chamber side wall with a chamber vacuum port. The vacuum source has a seal interposed in sealing engagement between the chamber vacuum port and the second elongate cannula. The device having a trigger slide assembly coupled to the housing body, and coupled to the cannula assembly. The trigger slide assembly is configured to move the second elongate cannula to align the vacuum side port of the second elongate cannula with the chamber vacuum port of the vacuum source to supply vacuum from the vacuum source to the second lumen of the second elongate cannula. The biopsy device herein is configured to be easy to use and permits an efficient vacuum application to aid in sample acquisition.
