A biopsy device includes a housing body, and a cannula assembly that has a first elongate cannula and a second elongate cannula coaxial with the first elongate cannula. The second elongate cannula has a lumen and a side wall having a vacuum side port in fluid communication with the lumen. A vacuum source is positioned in the housing body. The vacuum source has a chamber side wall having a chamber vacuum port. A seal is interposed in sealing engagement between the chamber vacuum port and the second elongate cannula. A trigger slide assembly is coupled to the housing body, and coupled to the cannula assembly, and is configured to move the second elongate cannula to align the vacuum side port of the second elongate cannula with the chamber vacuum port of the vacuum source to supply vacuum from the vacuum source to the lumen of the second elongate cannula.
