RECOMBINANT MYCOBACTERIUM ENCODING A HEPARIN-BINDING HEMAGGLUTININ (HBHA) FUSION PROTEIN AND USES THEREOF

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专利权人:

AERAS GLOBAL TB VACCINE FOUNDATION

发明人:

FULKERSON, JOHN,BRENNAN, MICHAEL,VELMURUGAN, KAMALAKANNAN,LOCHT, CAMILLE

申请号：

EP12874533

公开号：

EP2838990A4

申请日:

2012.04.16

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

Recombinant Mycobacteria (rMyc) which contain sequences encoding a heparin-binding hemagglutinin (HBHA) fusion protein are provided, as are methods of making and using the rMyc and the fusion protein. The fusion protein includes an amino terminal mycobacterial antigen Ag85B leader peptide and transcription of the fusion protein is driven by an Ag85B promoter sequence. The recombinant fusion protein is produced in abundance by the rMyc, is post-translationally methylated, and is highly antigenic.

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